betahistine and pregnancy

Betahistine sold under the brand name Serc among others is an anti-vertigo medication. We identified and evaluated the outcomes of 27 pregnant women who were referred to Terafar Teratology Information Service Izmir Turkey for a teratological risk assessment.

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If betahistine use is perceived as essential the baby should be observed for drowsiness GI disturbance and rash.

. For these reasons before you start taking betahistine it is important that your doctor knows. Animal studies are insufficient with respect to effects on pregnancy embryonalfoetal development parturition and postnatal development. To investigate the pregnancy outcomes of women who were exposed to betahistine during their pregnancies.

Additionally pregnant or lactating women shouldnt take betahistine since there are no studies on this medications effects under these circumstances. Preferably all drug usage including. Main exclusion criteria.

There are no adequate data from the use of betahistine in pregnant women. Pregnancy For betahistine dihydrochloride Avoid unless clearly necessaryno information available. Seventeen pregnancies with maternal betahistine expo- sure were retrieved.

Firstly it increases dose-dependent cochlear blood flow 27 mainly via the h3 receptor as an inverse agonist. The effects post-partum seen in animal studies were limited to very high doses. The potential risk for humans is unknown.

28 because betahistine has a strong first pass effect and is metabolised in the liver into three metabolites not only betahistine but also its major metabolite aminoethylpyridine increases cochlear blood flow. Women at risk of delivering prematurely used to be given multiple courses of steroids but this was associated with lower birth weights and smaller heads. If possible the pruritus and other allergic manifestations in the first trimester of pregnancy should be managed using topical medications like bland emollients and systemic antihistamines should be avoided as none of the antihistamines are categorized as safe by the FDA and in India no specific guidelines exist regarding their use in pregnancy.

Plasma levels of betahistine are very low. As a precautionary measure it is preferable to avoid the use of betahistine during pregnancy. However your doctor may prescribe betahistine if they think the benefits of taking this medicine outweigh the risks.

Safety of Betahistine Dihydrochloride during pregnancy has not been established. The median daily dose of betahistine was 24 mgday and the duration of exposure varied between 1 and 71 days of pregnancy with the oral route of administration in all of the pregnancies. This drug should be administered to pregnant patients or women suspected of being pregnant only if the expected therapeutic benefit is thought to outweigh any possible risk.

The malformation rate calculations were restricted to first trimester exposures that resulted only in live births due to the unavailability of data regarding major congenital malformations from the pathological examinations of miscarriages and elective terminations. Animal studies have not been conducted. Plasma protein binding.

Summarises key findings and provides detailed practical recommendations on the use of medicines during pregnancy and breastfeeding to support the clinical decision making process. There are no animal studies on use during lactation. It was first registered in Europe in 1970 for the treatment of Ménières disease.

27 cases with an exposure to betahistine during pregnancy were identified in the period between 2009 2017. Contraindications of betahistine treatment middle- or inner-ear infection psychiatric or significant neurological disorders spinal-cord damage use of any other agents for peripheral vestibular vertigo ear surgery for vestibular disorders pregnancy or breastfeeding and previous betahistine therapy 4 weeks. If you have ever had a stomach ulcer.

If you have asthma. The manufacturer makes no recommendation regarding use during pregnancy. Lactation It is not known whether betahistine is excreted in breast milk in humans.

As a precautionary measure it is preferable to avoid the use of Betahistine during pregnancy. There are no controlled data in human pregnancy. Before taking betahistine Some medicines are not suitable for people with certain conditions and sometimes a medicine can only be used if extra care is taken.

Peer reviewed and is constantly updated. Betahistine has been widely used in the symptomatic treatment of Menières disease and peripheral or central vertigo of varying etiology This article reviews relevant aspects of. Downloadable medicine fact sheets for patients.

-There is no data on use in pregnant women to know this drugs risks including the risk of fetal harm or reproductive effects. Speak to your doctor if you are pregnant or trying for a baby. Betahistine is excreted in rat milk.

Patterns of betahistine exposure. Breast feeding For betahistine dihydrochloride Use only if potential benefit outweighs riskno information available. All available information is fully referenced.

Research has found that when given late in pregnancy and in small doses the side effects of betamethasone are minimal 1 2 8. Medicinal forms There can be variation in the licensing of different medicines containing the same drug. This medicine is not recommended for pregnant women unless absolutely necessary.

Regarding adverse reactions for this medication its important to note the following. Gastrointestinal problems Disorders of the nervous system Immunologic disorders. Pregnancy Breastfeeding use.

All exposures occurred during the first trimester. Betahistine is used for Hearing Loss Tinnitus Vertigo etc. It will depend on how many weeks pregnant you are and why you need to take it.

Discuss with your doctor about the potential benefits and risks of. Today repeated courses are generally not recommended 1 8 9. BETAHISTINE HYDROCHLORIDE 8MG TABLETS Leaflet Scheme RecINN ATC Anatomical Therapeutic Chemical Classification N07CA01 CAS registry number Chemical Abstracts Service 0005638-76-6 Chemical Formula C8-H12-N2 Molecular Weight 136 Therapeutic Categories Agonist of histamine Antivertigo agent Chemical Name 2- 2-metylaminoetylpyridine WHO.

Betahistine is not usually recommended during pregnancy or while breastfeeding. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms eg. The mean maternal gestational age at.

Those associated with Ménières disease. If you are pregnant or breastfeeding.

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